A Trivariate Weibull Model For Oestradiol Plus Progestrone Treatment During The Preovulatory Period In Normal Premenopasual Women

In the previous studies a hypothesis was developed from the results that the increase in leptin concentrations during the second half of the menstrual cycle may be related to changes in the steroidal milieu during the preovulatory period and the luteal phase. The present study was undertaken to test this hypothesis further by examining the effect of treatment with oestradiol and progesterone on leptine concentrations in normal pre menopausal women. The trivariate Weibull model is used for finding survival functions and probability density functions for corresponding values of oestradiol, LH and FSH for both untreated and treated with oestradiol and oestradiol plus progesterone respectively. Keyword: Trivariate Weibull, LH, FSH, oestradiol and progesterone 2010 AMS Classifications: 62HXX, 60EXX